L-histidine
Description
In Escherichia coli, the genes for histidine biosynthesis are arranged in a single polycistronic operon: hisL–hisG–hisD–hisC–hisB–hisH–hisA–hisF–hisI. The hisL gene encodes a leader peptide that mediates transcriptional attenuation in response to histidine availability, thereby regulating the expression of the full operon. When sufficient charged histidyl-tRNAs are present, translation of the hisL-encoded leader peptide occurs rapidly, promoting the formation of an intrinsic, rho-independent terminator and halting transcription of the operon [203].
Chemical Formula:
C6H9N3O2
Molecular Weight:
155.156 Daltons
Monoisotopic Mass:
156.0773015808 Daltons
SMILES:
C1(NC=NC=1CC(C(=O)[O-])[N+])
InChI:
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChIKey:
Synonyms
- glyoxaline-5-alanine
- α-amino-4-imidazoleproprionic acid
- (S)-α-amino-1H-imidazole-4-propanoic acid
- H
- histidine
- L-his
Databases
MetaCyc:
HIS
RefMet:
Histidine
BiGG:
his__L
MetaboLights:
MTBLC57595
HMDB:
HMDB00177
KEGG:
C00135
CAS:
71-00-1
PupChem (SID):
3435
CHEMBL:
CHEMBL17962
PDB-CCD:
HIS
3DMET:
B01171
NIKKAJI:
J4.881J
MediaDB:
compounds/709/
compounds/132/
MetaNetX:
MNXM134
KNApSAcK:
C00001363