Compound as reactive (1)
NADP+ + 5,6,7,8-tetrahydrofolate ← 7,8-dihydrofolate monoglutamate + NADPH + H+
Compound as product (1)
7,8-dihydropteroate + L-glutamate + ATP → 7,8-dihydrofolate monoglutamate + H+ + phosphate + ADP
Reversible reaction (2)
5,10-methylenetetrahydropteroyl mono-L-glutamate + dUMP ↔ 7,8-dihydrofolate monoglutamate + dTMP
5,10-methylenetetrahydropteroyl mono-L-glutamate + dCMP ↔ 7,8-dihydrofolate monoglutamate + 2'-deoxy-5-methylcytidylate