Compound as reactive (1)
creatine + H2O → sarcosine + urea
Compound as product (2)
Nω-phosphocreatine + H2O → creatine + phosphate
guanidinoacetate + S-adenosyl-L-methionine → creatine + S-adenosyl-L-homocysteine + H+
Reversible reaction (2)
creatine + ATP ↔ Nω-phosphocreatine + H+ + ADP
H2O + creatinine ↔ creatine