Compound as reactive (1)

4'-phosphopantetheine + H⁺ + ATP → 3'-dephospho-CoA + diphosphate

Compound as product (2)

(R)-4'-phosphopantothenoyl-L-cysteine + H⁺ → 4'-phosphopantetheine + CO₂

pantetheine + ATP → 4'-phosphopantetheine + H⁺ + ADP

Reversible reaction (1)

coenzyme A + H₂O ↔ 2 H⁺ + 4'-phosphopantetheine + adenosine 3',5'-bisphosphate