Compound as reactive (3)

L-glutamate-5-semialdehyde + acetyl-CoA → coenzyme A + N-acetyl-L-glutamate 5-semialdehyde + H⁺

H₂O + L-glutamate-5-semialdehyde + NAD⁺ → 2 H⁺ + NADH + L-glutamate

H₂O + L-glutamate-5-semialdehyde + NADP⁺ → H⁺ + L-glutamate + NADPH

Compound as product (3)

L-glutamate-5-semialdehyde + NADP⁺ + phosphate ← γ-L-glutamyl 5-phosphate + NADPH + H⁺

NADPH + H⁺ + L-glutamate + ATP → L-glutamate-5-semialdehyde + NADP⁺ + phosphate + ADP

H₂O + (2S)-2-amino-5-iminopentanoate + H⁺ → L-glutamate-5-semialdehyde + ammonium

Reversible reaction (3)

L-glutamate-5-semialdehyde ↔ H₂O + H⁺ + (S)-1-pyrroline-5-carboxylate

L-ornithine + 2-oxoglutarate ↔ L-glutamate-5-semialdehyde + L-glutamate

L-ornithine + a 2-oxo acid ↔ L-glutamate-5-semialdehyde