Compound as reactive (1)

2 H⁺ + H₂O + L-citrulline → L-ornithine + ammonium + CO₂

Compound as product (6)

H₂O + N-acetyl-L-citrulline → acetate + L-citrulline

H₂O + N⁶,N⁶-dimethyl-L-arginine → L-citrulline + dimethylamine

L-arginine + m oxygen + n NADPH → L-citrulline + nitric oxide + n NADP⁺

2 L-arginine + 3 NADPH + 4 oxygen + H⁺ → 2 L-citrulline + 2 nitric oxide + 3 NADP⁺ + 4 H₂O

2 N^ω-hydroxy-L-arginine + 2 oxygen + NADPH → 2 H₂O + 2 L-citrulline + 2 nitric oxide + NADP⁺ + H⁺

2 L-arginine + 3 NAD(P)H + 4 oxygen + H⁺ → 2 L-citrulline + 2 nitric oxide + 3 NAD(P)+ + 4 H₂O

Reversible reaction (4)

L-citrulline + L-aspartate + ATP ↔ L-arginino-succinate + H⁺ + diphosphate + AMP

H₂O + L-arginine ↔ L-citrulline + ammonium

2 N^ω-hydroxy-L-arginine + 2 oxygen + NAD(P)H ↔ 2 H₂O + 2 L-citrulline + 2 nitric oxide + NAD(P)+ + H⁺

L-ornithine + carbamoyl phosphate ↔ L-citrulline + H⁺ + phosphate