Compound as reactive (1)

(R)-5-phosphomevalonate + ATP → isopentenyl phosphate + phosphate + ADP + CO₂

Compound as product (3)

(R)-mevalonate + CTP → (R)-5-phosphomevalonate + CDP + H+

(R)-mevalonate + GTP → (R)-5-phosphomevalonate + GDP + H+

(R)-mevalonate + UTP → (R)-5-phosphomevalonate + H+ + UDP

Reversible reaction (2)

(R)-mevalonate + ATP ↔ (R)-5-phosphomevalonate + H⁺ + ADP

(R)-5-phosphomevalonate + ATP ↔ (R)-mevalonate diphosphate + ADP