Compound as reactive (1)
(R)-pantoate + NADP+ ← NADPH + 2-dehydropantoate + H+
Compound as product (2)
H2O + 3-methyl-2-oxobutanoate + 5,10-methylenetetrahydropteroyl mono-L-glutamate → 2-dehydropantoate + 5,6,7,8-tetrahydrofolate
H2O + 5,10-methylene-tetrahydromethanopterin + 3-methyl-2-oxobutanoate → tetrahydromethanopterin + 2-dehydropantoate
Reversible reaction (1)
2-dehydropantoate ↔ 3-methyl-2-oxobutanoate + formaldehyde