Compound as reactive (4)

(R)-2-hydroxy-4-methylpentanoate + NADP⁺ ← NADPH + 4-methyl-2-oxopentanoate + H⁺

4-methyl-2-oxopentanoate + oxygen → 3-hydroxy-3-methylbutanoate + CO₂

4-methyl-2-oxopentanoate + H⁺ → 3-methylbutanal + CO₂

coenzyme A + 4-methyl-2-oxopentanoate + NAD⁺ → NADH + isovaleryl-CoA + CO₂

Compound as product (3)

(2R,3S)-3-isopropylmalate + NAD⁺ → NADH + 4-methyl-2-oxopentanoate + CO₂

H₂O + NAD⁺ + L-leucine → NADH + 4-methyl-2-oxopentanoate + H⁺ + ammonium

(2S)-2-isopropyl-3-oxosuccinate + H⁺ → 4-methyl-2-oxopentanoate + CO₂

Reversible reaction (4)

2 an oxidized ferredoxin [iron-sulfur] cluster + coenzyme A + 4-methyl-2-oxopentanoate ↔ 2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ + isovaleryl-CoA + CO₂

2-oxoglutarate + L-leucine ↔ 4-methyl-2-oxopentanoate + L-glutamate

NADH + 4-methyl-2-oxopentanoate + H⁺ ↔ (R)-2-hydroxy-4-methylpentanoate + NAD⁺

H₂O + NADP⁺ + L-leucine ↔ ammonia + NADPH + 4-methyl-2-oxopentanoate