Compound as reactive (1)

S-adenosyl-L-methionine + isoscopoletin → S-adenosyl-L-homocysteine + H⁺ + scoparone

Compound as product (1)

S-adenosyl-L-methionine + esculetin → S-adenosyl-L-homocysteine + H⁺ + isoscopoletin

Reversible reaction (2)

isoscopoletin ↔ 2 H⁺ + ayapin

herniarin ↔ isoscopoletin