H₂O + S-adenosyl-L-methionine + 12-ethyl-7¹-hydroxy-8-propylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹,7¹-dihydroxy-8-propylbacteriochlorophyllide c

5-amino-1-(5-phospho-β-D-ribosyl)imidazole + S-adenosyl-L-methionine → 3 H⁺ + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + formate + 5'-deoxyadenosine + L-methionine + carbon monoxide

2 S-adenosyl-L-methionine + a reduced electron donor + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 5'-deoxyadenosine + L-methionine

2 S-adenosyl-L-methionine + H₂O + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide e

S-adenosyl-L-methionine + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester → 2 H⁺ + 5'-deoxyadenosine + L-methionine + 3,8-divinyl protochlorophyllide a

H₂O + S-adenosyl-L-methionine + (3¹R)-8,12-diethylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8,12-diethyl-7¹-hydroxybacteriochlorophyllide c

S-adenosyl-L-methionine + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester → H⁺ + 5'-deoxyadenosine + L-methionine + 13¹-oxo-magnesium-protoporphyrin IX 13-monomethyl ester

2 S-adenosyl-L-methionine + Fe-coproporphyrin III → 2 5'-deoxyadenosine + 2 L-methionine + 2 CO₂ + protoheme

hop-22(29)-ene + S-adenosyl-L-methionine + a reduced electron donor → an oxidized electron donor + H⁺ + L-methionine + adenosyl hopane

S-adenosyl-L-methionine + 5-amino-6-(D-ribitylamino)uracil + L-tyrosine → 2 H⁺ + 2-iminoacetate + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + a reduced electron donor + L-tyrosine → 2 H⁺ + an oxidized electron donor + 2-iminoacetate + 5'-deoxyadenosine + L-methionine + 4-methylphenol

H₂O + glycyl-L-methionine → glycine + L-methionine

H₂O + S-adenosyl-L-methionine + 12-ethyl-8-propylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹-hydroxy-8-propylbacteriochlorophyllide c

2 S-adenosyl-L-methionine + a reduced electron donor + N-acetyldemethyl-L-phosphinothricin → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricin + 5'-deoxyadenosine + L-methionine

2 S-adenosyl-L-methionine + 2 a reduced electron donor + 12,18-didecarboxysiroheme → 2 an oxidized electron donor + 2 acetate + 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + Fe-coproporphyrin III

2 S-adenosyl-L-methionine + coproporphyrinogen III → 2 5'-deoxyadenosine + 2 L-methionine + 2 CO₂ + protoporphyrinogen IX

L-homocysteine + S-methyl-L-methionine → 2 L-methionine + H⁺

2 S-adenosyl-L-methionine + H₂O + (3¹R)-8,12-diethylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + (3¹R)-8,12-diethylbacteriochlorophyllide e

2 S-adenosyl-L-methionine + H₂O + 12-ethyl-8-propylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + 12-ethyl-8-propylbacteriochlorophyllide e

S-adenosyl-L-methionine + dehypoxanthine futalosine → H⁺ + 5'-deoxyadenosine + L-methionine + cyclic dehypoxanthine futalosine

H₂O + S-adenosyl-L-methionine + 12-ethyl-8-isobutylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹-hydroxy-8-isobutylbacteriochlorophyllide c

H₂O + S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate → H⁺ + L-methionine + hydrogencarbonate + 6-amino-6-deoxyfutalosine

H₂O + S-adenosyl-L-methionine + magnesium-protoporphyrin IX 13-monomethyl ester → H⁺ + 5'-deoxyadenosine + L-methionine + 13¹-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

S-adenosyl-L-methionine + a reduced electron donor + GTP → an oxidized electron donor + (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + H⁺ + 5'-deoxyadenosine + L-methionine

2 S-adenosyl-L-methionine + a reduced electron donor + N-acetyldemethylphosphinothricin tripeptide → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricin tripeptide + 5'-deoxyadenosine + L-methionine

2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricyl-L-alanyl-L-leucine + a reduced electron donor → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricyl-L-alanyl-L-leucine + 5'-deoxyadenosine + L-methionine

H₂O + S-adenosyl-L-methionine + (3¹R)-8,12-diethyl-7¹-hydroxybacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8,12-diethyl-7¹,7¹-dihydroxybacteriochlorophyllide c

O-acetyl-L-homoserine + methanethiol → acetate + H⁺ + L-methionine

α-D-ribose-1-[N-(phosphonomethyl)glycine] 5-phosphate + S-adenosyl-L-methionine + a reduced electron donor → an oxidized electron donor + 5-phospho-α-D-ribose 1,2-cyclic phosphate + sarcosine + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + methylcob(III)alamin + hopan-22-ol → 5'-deoxyadenosine + L-methionine + 2-methyldiplopterol + cob(III)alamin

NADPH + S-adenosyl-L-methionine + L-tyrosine → 2-iminoacetate + NADP⁺ + H⁺ + 5'-deoxyadenosine + L-methionine + 4-methylphenol

2 S-adenosyl-L-methionine + H₂O + 12-ethyl-8-isobutylbacteriochlorophyllide c → 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + 12-ethyl-8-isobutylbacteriochlorophyllide e

S-adenosyl-L-methionine + methylcob(III)alamin + bacteriohopanetetrol → 5'-deoxyadenosine + L-methionine + 2-methylbacteriohopanetetrol + cob(III)alamin

L-homocysteine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + L-methionine

S-adenosyl-L-methionine + dTDP-viosamine + a reduced electron donor → an oxidized electron donor + dTDP-3-dehydro-4,6-deoxy-α-D-glucose + H⁺ + ammonium + 5'-deoxyadenosine + L-methionine

L-homocysteine + 5-methyltetrahydropteroyl mono-L-glutamate → L-methionine + 5,6,7,8-tetrahydrofolate

α-D-ribose-1-(2-N-acetamidomethylphosphonate) 5-phosphate + S-adenosyl-L-methionine + a reduced electron donor → an oxidized electron donor + 5-phospho-α-D-ribose 1,2-cyclic phosphate + H⁺ + 5'-deoxyadenosine + L-methionine + N-methylacetamide

H₂O + S-adenosyl-L-methionine + 12-ethyl-7¹-hydroxy-8-isobutylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + 12-ethyl-7¹,7¹-dihydroxy-8-isobutylbacteriochlorophyllide c

S-adenosyl-L-methionine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil → 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H⁺ + ammonium + 5'-deoxyadenosine + L-methionine

H₂O + N-formyl-L-methionine → formate + L-methionine

hop-22(29)-ene + S-adenosyl-L-methionine + H⁺ → L-methionine + adenosyl hopane

α-D-ribose-1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + a reduced electron donor → an oxidized electron donor + methane + 5-phospho-α-D-ribose 1,2-cyclic phosphate + H⁺ + 5'-deoxyadenosine + L-methionine

H₂O + S-adenosyl-L-methionine + (3¹R)-8-ethyl-7¹-12-methylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8-ethyl-7¹,7¹-dihydroxy-12-methylbacteriochlorophyllide c

3 S-adenosyl-L-methionine + H₂O + magnesium-protoporphyrin IX 13-monomethyl ester → 3 5'-deoxyadenosine + 3 L-methionine + 4 H⁺ + 3,8-divinyl protochlorophyllide a

H₂O + L-methionyl-L-alanine dipeptide → L-methionine + L-alanine

2 H₂O + 2 S-adenosyl-L-methionine + 12,18-didecarboxysiroheme → 2 propanoate + 2 H⁺ + 2 5'-deoxyadenosine + 2 L-methionine + pre-heme d₁

S-adenosyl-L-methionine + 2-deoxy-scyllo-inosamine → 3-amino-2,3-dideoxy-scyllo-inosose + H⁺ + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + methylcob(III)alamin + tetrahymanol → 2-methyltetrahymanol + 5'-deoxyadenosine + L-methionine + cob(III)alamin

5-amino-1-(5-phospho-β-D-ribosyl)imidazole + S-adenosyl-L-methionine → 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate → (S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + L-methionine + cob(III)alamin

S-adenosyl-L-methionine + fluoride → L-methionine + 5'-deoxy-5'-fluoroadenosine

9-mercaptodethiobiotin + S-adenosyl-L-methionine → biotin + H⁺ + 5'-deoxyadenosine + L-methionine

H₂O + S-adenosyl-L-methionine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide c → H⁺ + 5'-deoxyadenosine + L-methionine + (3¹R)-8-ethyl-7¹-12-methylbacteriochlorophyllide c

5-amino-1-(5-phospho-β-D-ribosyl)imidazole + S-adenosyl-L-methionine + a reduced electron donor → 2 H⁺ + an oxidized electron donor + 5-hydroxybenzimidazole + formate + ammonium + 5'-deoxyadenosine + L-methionine + phosphate

H₂O + S-adenosyl-L-methionine → adenosine + H⁺ + L-methionine

2 S-adenosyl-L-methionine + H₂O + 3-(4-hydroxyphenyl)pyruvate + 5-amino-6-(D-ribitylamino)uracil → 2 5'-deoxyadenosine + 2 L-methionine + 3 H⁺ + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + ammonium + oxalate

Reversible reaction (16)

L-methionine ↔ D-methionine

S-adenosyl-L-methionine + methylcob(III)alamin + N-acetyldemethylphosphinothricin tripeptide ↔ N-acetylphosphinothricin tripeptide + 5'-deoxyadenosine + L-methionine + cob(III)alamin

4 H⁺ + L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate ↔ L-methionine + tetrahydropteroyl tri-L-glutamate

O-succinyl-L-homoserine + methanethiol ↔ H⁺ + L-methionine + succinate

glyoxylate + L-methionine ↔ glycine + 4-(methylsulfanyl)-2-oxobutanoate

S-adenosyl-L-methionine + dehypoxanthine futalosine ↔ 2 H⁺ + L-methionine + cyclic dehypoxanthine futalosine + 5'-deoxyadenosin-5'-yl radical

2-oxoglutarate + L-methionine ↔ 4-(methylsulfanyl)-2-oxobutanoate + L-glutamate

S-methyl-L-methionine + L-selenocysteine ↔ H⁺ + L-methionine + Se-methyl-L-selenocysteine

2-oxoglutaramate + L-methionine ↔ 4-(methylsulfanyl)-2-oxobutanoate + L-glutamine

H₂O + L-methionine + ATP ↔ L-methionine + phosphate + ADP

3-phenyl-2-oxopropanoate + L-methionine ↔ L-phenylalanine + 4-(methylsulfanyl)-2-oxobutanoate

H⁺ + L-methionine ↔ 3-(methylsulfanyl)propanamine + CO₂

S-adenosyl-L-methionine + chloride ↔ 5'-chloro-5'-deoxyadenosine + L-methionine

L-homocysteine + thetin ↔ (methylsulfanyl)acetate + H⁺ + L-methionine

L-methionine + (indol-3-yl)pyruvate ↔ 4-(methylsulfanyl)-2-oxobutanoate + L-tryptophan

L-methionine + H⁺ ↔ L-methionine + H⁺

Compound as reactive (12)

Compound as product (57)

Reversible reaction (16)