Compound as reactive (1)

5-(2-hydroxyethyl)-4-methylthiazole + ATP → H⁺ + 4-methyl-5-(2-phosphooxyethyl)thiazole + ADP

Compound as product (2)

thiamine + H₂O → 4-amino-2-methyl-5-pyrimidinemethanol + H⁺ + 5-(2-hydroxyethyl)-4-methylthiazole

H₂O + oxythiamine → H⁺ + 5-(2-hydroxyethyl)-4-methylthiazole + 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone

Reversible reaction (1)

thiamine + pyridine ↔ heteropyrithiamine + 5-(2-hydroxyethyl)-4-methylthiazole