Compound as reactive (15)

11 H⁺ + 5 NADPH + 5 (S)-methylmalonyl-CoA + malonyl-CoA → 2 H₂O + 5 NADP⁺ + 6 coenzyme A + 6 CO₂ + 10-deoxymethynolide

11 NADPH + 2 (S)-methylmalonyl-CoA + 22 H⁺ + 9 malonyl-CoA → 11 coenzyme A + 11 NADP⁺ + 11 CO₂ + 5 H₂O + spinosyn macrolactone

NADPH + H⁺ + palmitoleoyl-CoA + (S)-methylmalonyl-CoA → 2 coenzyme A + 2-methyl-octadec-2,9-dienoate + NADP⁺ + CO₂

H⁺ + Na⁺ + (S)-methylmalonyl-CoA → propanoyl-CoA + Na⁺ + CO₂

11 NADPH + 11 H⁺ + 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA → 11 NADP⁺ + 3 H₂O + 8 coenzyme A + 8 CO₂ + tylactone

15 malonyl-CoA + 28 NADPH + 4 (S)-methylmalonyl-CoA + 47 H⁺ + 4-aminobenzoyl-CoA → 15 CO₂ + 16 H₂O + 20 coenzyme A + 28 NADP⁺ + candicinolide

H⁺ + (S)-methylmalonyl-CoA → propanoyl-CoA + CO₂

12 H⁺ + 6 NADPH + 6 (S)-methylmalonyl-CoA + acetyl-CoA → 6 NADP⁺ + 6 CO₂ + 7 coenzyme A + H₂O + 8,8a-deoxyoleandolide

15 malonyl-CoA + 19 NADPH + 3 (S)-methylmalonyl-CoA + 37 H⁺ + acetyl-CoA → 18 CO₂ + 19 coenzyme A + 19 NADP⁺ + 8 H₂O + decarboxy-dehydroxy-demycosaminyl-nystatin

12 H⁺ + 6 NADPH + 6 (S)-methylmalonyl-CoA + propanoyl-CoA → 6 NADP⁺ + 6 CO₂ + 7 coenzyme A + H₂O + 6-deoxyerythronolide B

15 H⁺ + 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 7 NADPH + (2S)-ethylmalonyl-CoA → 3 H₂O + 7 NADP⁺ + 8 coenzyme A + 8 CO₂ + tylactone

12 H⁺ + 5 NADPH + 6 (S)-methylmalonyl-CoA + malonyl-CoA → 2 H₂O + 5 NADP⁺ + 7 coenzyme A + 7 CO₂ + narbonolide

H₂O + (S)-methylmalonyl-CoA → coenzyme A + methylmalonate + H⁺

15 H⁺ + 3 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 7 NADPH → 4 H₂O + 7 NADP⁺ + 8 coenzyme A + 8 CO₂ + protomycinolide IV

22 NADPH + 32 H⁺ + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + heptanoyl-CoA → 10 coenzyme A + 10 CO₂ + 11 H₂O + 22 NADP⁺ + C32-mycoketide-CoA

Compound as product (1)

succinyl-CoA → (S)-methylmalonyl-CoA

Reversible reaction (4)

propanoyl-CoA + hydrogencarbonate + ATP ↔ H⁺ + (S)-methylmalonyl-CoA + phosphate + ADP

H₂O + propanoyl-CoA + ATP + CO₂ ↔ (S)-methylmalonyl-CoA + phosphate + ADP

pyruvate + (S)-methylmalonyl-CoA ↔ propanoyl-CoA + oxaloacetate

(R)-methylmalonyl-CoA ↔ (S)-methylmalonyl-CoA