2 H+ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H2O + Fe2+ + biliverdin-IX δ + carbon monoxide
2 H+ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H2O + Fe2+ + biliverdin-IX β + carbon monoxide
H2O + protoheme + (2E,6E)-farnesyl diphosphate → diphosphate + ferroheme o
2 H+ + 4 oxygen + 5 a reduced electron donor + protoheme → 4 H2O + 5 an oxidized electron donor + Fe2+ + formaldehyde + δ-staphylobilin
H2O + protoheme + (2E,6E)-farnesyl diphosphate → heme o + diphosphate
H2O + protoheme + ATP → H+ + phosphate + protoheme + ADP
2 H+ + 4 a reduced electron donor + 4 oxygen + protoheme → 4 an oxidized electron donor + 4 H2O + Fe2+ + β-staphylobilin + carbon monoxide
2 H+ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H2O + Fe2+ + mycobilin b
2 H+ + 2 oxygen + an oxidized electron donor + hydrogen peroxide + protoheme → 2 carbon monoxide + hematinate + a reduced electron donor + tripyrrole + Fe3+
2 H+ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H2O + Fe2+ + mycobilin a
2 H+ + 4 oxygen + 5 a reduced electron donor + protoheme → 4 H2O + 5 an oxidized electron donor + Fe2+ + formaldehyde + β-staphylobilin
2 H+ + 4 a reduced electron donor + 4 oxygen + protoheme → 4 an oxidized electron donor + 4 H2O + Fe2+ + δ-staphylobilin + carbon monoxide
3 oxygen + 6 a reduced ferredoxin [iron-sulfur] cluster + 8 H+ + protoheme → 3 H2O + 6 an oxidized ferredoxin [iron-sulfur] cluster + Fe2+ + (Z,Z)-biliverdin-IX α + carbon monoxide
2 H+ + 3 a reduced electron donor + 3 oxygen + protoheme → 3 an oxidized electron donor + 3 H2O + Fe2+ + (Z,Z)-biliverdin-IX α + carbon monoxide