Compound as reactive (2)

an oxidized electron donor + (R)-2-hydroxyglutarate → a reduced electron donor + 2-oxoglutarate

4 H⁺ + acetyl-CoA + (R)-2-hydroxyglutarate → acetate + (R)-2-hydroxyglutaryl-CoA

Compound as product (2)

2-oxoglutarate + 4-hydroxybutanoate → succinate semialdehyde + (R)-2-hydroxyglutarate

2-oxoadipate + oxygen → (R)-2-hydroxyglutarate + CO₂

Reversible reaction (4)

oxaloacetate + (R)-2-hydroxyglutarate ↔ (R)-malate + 2-oxoglutarate

pyruvate + (R)-2-hydroxyglutarate ↔ 2-oxoglutarate + (R)-lactate

NAD⁺ + (R)-2-hydroxyglutarate ↔ NADH + 2-oxoglutarate + H⁺

(S)-3-hydroxybutanoate + 2-oxoglutarate ↔ acetoacetate + (R)-2-hydroxyglutarate