Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications
Titer in Flask for L-(-)-3-Phenyllactic acid
| Modifications | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrAEc | tyrBEc | pprLs | trpEEc | ptsHEc | ptsIEc | crrEc | glfZm | glkZm | aroGEc | pheAEc | tktAEc | pckEc | ghrBEc | pprAWf | ldhLBc | fdhCb |
| E. coli CGSC4510 | 28 mg/L | |||||||||||||||||
| E. coli MG-P2 | 189 mg/L | |||||||||||||||||
| E. coli MG-P3 | 212 mg/L | |||||||||||||||||
| E. coli MG-P1 | 251 mg/L | |||||||||||||||||
| E. coli MG-P4 | 417 mg/L | |||||||||||||||||
| E. coli MP-P5 | 578 mg/L | |||||||||||||||||
| E. coli MG-P6 | 717.4 mg/L | |||||||||||||||||
| E. coli MG-P7 | 880 mg/L | |||||||||||||||||
| E. coli MG-P8 | 1,140 mg/L | |||||||||||||||||
| E. coli MG-P9 | 1,210 mg/L | |||||||||||||||||
| E. coli MG-P10 | 1,420 mg/L | |||||||||||||||||
| E. coli BL21(pETDuet-ldhL-fdh) | 13,227.132 mg/L | |||||||||||||||||
Titer in Fed-Batch for L-(-)-3-Phenyllactic acid
| Modifications | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrAEc | tyrBEc | pprLs | trpEEc | ptsHEc | ptsIEc | crrEc | glfZm | glkZm | aroGEc | pheAEc | tktAEc | pckEc |
| E. coli MG-P10 | 52,890 mg/L | |||||||||||||
Substrate yield in Fed-Batch for L-(-)-3-Phenyllactic acid
| Modifications | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrAEc | tyrBEc | pprLs | trpEEc | ptsHEc | ptsIEc | crrEc | glfZm | glkZm | aroGEc | pheAEc | tktAEc | pckEc |
| E. coli MG-P10 | 0.225 g/g of sustrate | |||||||||||||
Substrate yield in Flask for L-(-)-3-Phenyllactic acid
| Modifications | |||
|---|---|---|---|
| Strain | Maximum production | ldhLBc | fdhCb |
| E. coli BL21(pETDuet-ldhL-fdh) | 0.961 g/g of sustrate | ||
Volumetric productivity in Fed-Batch for L-(-)-3-Phenyllactic acid
| Modifications | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrAEc | tyrBEc | pprLs | trpEEc | ptsHEc | ptsIEc | crrEc | glfZm | glkZm | aroGEc | pheAEc | tktAEc | pckEc |
| E. coli MG-P10 | 1,102 mg/L/h | |||||||||||||
Volumetric productivity in Flask for L-(-)-3-Phenyllactic acid
| Modifications | |||
|---|---|---|---|
| Strain | Maximum production | ldhLBc | fdhCb |
| E. coli BL21(pETDuet-ldhL-fdh) | -999,999,999 mg/L/h | ||