Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for shikimate

Modifications
Strain Maximum production aroLEc aroKEc ptsGEc pykFEc ydiBEc ackAEc ptaEc aroGEc ppsAEc tktAEc
E. coli W3110 1.13 mg/L
E. coli B0013 1.63 mg/L
E. coli SA1 21.45 mg/L
E. coli SA2 67.81 mg/L
E. coli SA4* 385.62 mg/L
E. coli SA3 417.2 mg/L
E. coli SA4 576.17 mg/L
E. coli SA5 670.04 mg/L
E. coli SA5/pTH-aroG* 900 mg/L
E. coli SA5/pTH-aroG*-ppsA 1,080 mg/L
E. coli SA5/pTH-aroG*-ppsA-tktA 1,207 mg/L

Titer in Fed-Batch for shikimate

Modifications
Strain Maximum production aroLEc aroKEc ptsGEc ydiBEc ackAEc ptaEc aroGEc ppsAEc tktAEc
E. coli SA5/pTH-aroG*-ppsA-tktA 14,600 mg/L

Substrate yield in Flask for shikimate

Modifications
Strain Maximum production aroLEc aroKEc ptsGEc ydiBEc ackAEc ptaEc aroGEc ppsAEc tktAEc
E. coli SA5/pTH-aroG*-ppsA-tktA 0.0851 g/g of sustrate

Substrate yield in Fed-Batch for shikimate

Modifications
Strain Maximum production aroLEc aroKEc ptsGEc ydiBEc ackAEc ptaEc aroGEc ppsAEc tktAEc
E. coli SA5/pTH-aroG*-ppsA-tktA 0.2925 g/g of sustrate

Volumetric productivity in Flask for shikimate

Modifications
Strain Maximum production aroLEc aroKEc ptsGEc ydiBEc ackAEc ptaEc aroGEc ppsAEc tktAEc
E. coli SA5/pTH-aroG*-ppsA-tktA 47 mg/L/h

Volumetric productivity in Fed-Batch for shikimate

Modifications
Strain Maximum production aroLEc aroKEc ptsGEc ydiBEc ackAEc ptaEc aroGEc ppsAEc tktAEc
E. coli SA5/pTH-aroG*-ppsA-tktA 260 mg/L/h