Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for L-proline

Modifications
Strain Maximum production
E. coli PM-14 816 mg/L

Titer in Fed-Batch for L-proline

Modifications
Strain Maximum production putAEc putPEc proPEc aceAEc proBEc
E. coli M1 18,200 mg/L
E. coli M1/∆putP 20,500 mg/L
E. coli M1/∆proP 21,600 mg/L
E. coli M1/∆aceA 23,600 mg/L
E. coli M2 26,000 mg/L
E. coli M3 30,400 mg/L
E. coli M4 31,400 mg/L
E. coli M5 32,200 mg/L
E. coli M5/proBE143A 33,800 mg/L
E. coli M6 37,500 mg/L

Volumetric productivity in Fed-Batch for L-proline

Modifications
Strain Maximum production putAEc putPEc proPEc aceAEc proBEc
E. coli M1 455 mg/L/h
E. coli M1/∆putP 513 mg/L/h
E. coli M1/∆proP 540 mg/L/h
E. coli M1/∆aceA 590 mg/L/h
E. coli M2 650 mg/L/h
E. coli M3 760 mg/L/h
E. coli M4 785 mg/L/h
E. coli M5 805 mg/L/h
E. coli M5/proBE143A 845 mg/L/h
E. coli M6 938 mg/L/h