hypoxanthine charts

Silencing

Overexpression

Feedback insensitive

Attenuation

Feed-forward insensitive

Inhibition insensitive

Unstated

Combined modifications

Titer in Flask for hypoxanthine

		Modifications
Strain	Maximum production	xdhA_Ec	xdhB_Ec	xdhC_Ec	purR_Ec	purF_Ec	purF_Bs	prs_Ba	prsA_Ec	purD_Bs	purN_Bs	purT_Bs	purS_Bs	purQ_Bs	purL_Bs	purM_Bs	purK_Bs	purE_Bs	purC_Bs	purB_Bs	purA_Ec	purA_Bs	add_Ec	AAH1_Sc	add_St	adeD_Ec	ushA_Ec	umpH_Ec	umpG_Ec	ISN1_Sc	hpt_Ec	guaB_Ec	purB_Ec	glnA_Bs	aspC_Ec	thrA_Ec
E. coli W3110	0 mg/L
E. coli HX1	50 mg/L
E. coli HX2	100 mg/L
E. coli HX3-1	200 mg/L
E. coli HX3-2	320 mg/L
E. coli HX4-1	410 mg/L
E. coli HX1-1	490 mg/L
E. coli HX4-2	530 mg/L
E. coli Y2-1	600 mg/L
E. coli Y3-1	710 mg/L
E. coli HX5	940 mg/L
E. coli Y3-3	1,100 mg/L
E. coli Y2-3	1,110 mg/L
E. coli Y2-4	1,180 mg/L
E. coli Y3-2	1,250 mg/L
E. coli Y2-2	1,320 mg/L
E. coli Y1-2	1,380 mg/L
E. coli Y3-4	1,670 mg/L
E. coli Y4-1	1,950 mg/L
E. coli Y4-2	2,270 mg/L
E. coli Y5-4A	2,670 mg/L
E. coli Y4-3	2,890 mg/L
E. coli Y5-4C	3,190 mg/L
E. coli Y6-3	3,210 mg/L
E. coli Y5-4D	3,230 mg/L
E. coli Y5-4B	3,250 mg/L
E. coli Y6	3,300 mg/L
E. coli Y5-1	3,430 mg/L
E. coli Y6-1	3,610 mg/L
E. coli Y6-4	3,670 mg/L
E. coli Y6-2	3,840 mg/L
E. coli Y6-7	3,940 mg/L
E. coli Y6-6	4,020 mg/L
E. coli Y6-5	4,110 mg/L

Titer in Fed-Batch for hypoxanthine

		Modifications
Strain	Maximum production	xdhA_Ec	xdhB_Ec	xdhC_Ec	purR_Ec	purF_Bs	prsA_Ec	purD_Bs	purN_Bs	purT_Bs	purS_Bs	purQ_Bs	purL_Bs	purM_Bs	purK_Bs	purE_Bs	purC_Bs	purB_Bs	add_Ec	adeD_Ec	ISN1_Sc	hpt_Ec	guaB_Ec	purB_Ec	glnA_Bs	aspC_Ec	thrA_Ec
E. coli Y6-5	30,600 mg/L

Substrate yield in Flask for hypoxanthine

		Modifications
Strain	Maximum production	xdhA_Ec	xdhB_Ec	xdhC_Ec	purR_Ec	purF_Bs	prsA_Ec	purD_Bs	purN_Bs	purT_Bs	purS_Bs	purQ_Bs	purL_Bs	purM_Bs	purK_Bs	purE_Bs	purC_Bs	purB_Bs	add_Ec	adeD_Ec	ISN1_Sc	hpt_Ec	guaB_Ec	purB_Ec	glnA_Bs	aspC_Ec	thrA_Ec	ushA_Ec	umpH_Ec	umpG_Ec
E. coli Y4-1	0.03 g/g of sustrate
E. coli Y3-4	0.035 g/g of sustrate
E. coli Y4-2	0.046 g/g of sustrate
E. coli Y6-3	0.057 g/g of sustrate
E. coli Y4-3	0.06 g/g of sustrate
E. coli Y6-2	0.06 g/g of sustrate
E. coli Y6-4	0.062 g/g of sustrate
E. coli Y6	0.065 g/g of sustrate
E. coli Y6-7	0.067 g/g of sustrate
E. coli Y6-6	0.07 g/g of sustrate
E. coli Y6-1	0.071 g/g of sustrate
E. coli Y6-5	0.074 g/g of sustrate