Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for L-homoserine

Modifications
Strain Maximum production lysAEc thrBEc metAEc ldhAEc adhEEc pflBEc metLEc rhtAEc ptsGEc galPEc ppcEc iclREc arcAEc aspAEc glkEc asdEc glfZm atpFEc atpHEc galREc eamAEc thrAEc gltBEc pgkEc addEc amnEc ADO1Sc aspCEc sucAEc sucBEc flhCEc ompTEc rhtBEc pykAEc crpEc thrCEc gltAEc pykFEc lysCEc tdcCEc
E. coli W-H4 0 mg/L
E. coli W3110 0 mg/L
E. coli HM5 (pBRmetL–pNrhtA) 0.29 mg/L
E. coli W-H7 61.9424 mg/L
E. coli HM4 120 mg/L
E. coli LJL3 200 mg/L
E. coli W-8/pM1/pR1 258.4904 mg/L
E. coli HM4 (pBRlysCFbr) 350 mg/L
E. coli HM4 (pBRlysC) 400 mg/L
E. coli LJL8 500 mg/L
E. coli LJL9 800 mg/L
E. coli W-H7/pM1/pR1 960.1072 mg/L
E. coli HM4 (pBRmetL) 1,040 mg/L
E. coli HM4 (pBRthrAFbr) 1,110 mg/L
E. coli HM4 (pBRthrA) 1,200 mg/L
E. coli HM4 (pBRmetL–rhtA) 1,420 mg/L
E. coli LJL10 1,700 mg/L
E. coli HM4 (pBRmetL–rhtA23) 1,810 mg/L
E. coli LJL11 2,100 mg/L
E. coli LJL12 3,200 mg/L
E. coli HS4 3,570 mg/L
E. coli W-9/pM1/pR1 4,288.32 mg/L
E. coli W-10/pM1/pR1 5,122.16 mg/L
E. coli W-H15/pM2/pR2 5,479.52 mg/L
E. coli W-13/pM1/pR1 5,793.9968 mg/L
E. coli W-H16/pM2/pR2 6,194.24 mg/L
E. coli W-12/pM1/pR1 6,357.4344 mg/L
E. coli W-H17/pM1/pR1 6,396.744 mg/L
E. coli W-11/pM1/pR1 7,278.232 mg/L
E. coli HS2 7,560 mg/L
E. coli W-14/pM1/pR1 7,587.944 mg/L
E. coli HS17 8,860 mg/L
E. coli HS9 8,950 mg/L
E. coli HS10 8,960 mg/L
E. coli HS1 8,970 mg/L
E. coli W-H15/pM1/pR1 9,207.976 mg/L
E. coli HS6 9,230 mg/L
E. coli HS12 9,640 mg/L
E. coli HS3 9,690 mg/L
E. coli HS5 10,150 mg/L
E. coli HS7 10,300 mg/L
E. coli HS16 10,420 mg/L
E. coli W-H17/pM2/pR1 10,613.592 mg/L
E. coli W-H17/pM2/pR2 11,125.808 mg/L
E. coli HS11 11,880 mg/L
E. coli W-H19/pM2/pR1 12,400 mg/L
E. coli W-H18/pM2/pR1 12,500 mg/L
E. coli W-H20/pM2/pR1 12,700 mg/L
E. coli HS26 13,210 mg/L
E. coli HS 13,390 mg/L
E. coli HS22 14,260 mg/L
E. coli HS18 16,490 mg/L
E. coli HS19 16,870 mg/L
E. coli HS8 18,400 mg/L
E. coli HS15 19,400 mg/L
E. coli HS25 19,550 mg/L
E. coli HS13 20,000 mg/L
E. coli HS20 21,090 mg/L
E. coli HS14 21,380 mg/L
E. coli HS23 23,180 mg/L
E. coli HS21 23,630 mg/L
E. coli HS24 29,200 mg/L
E. coli HS27 32,550 mg/L
E. coli HM4 (pBRmetL–pNrhtA) 33,420 mg/L

Titer in Fed-Batch for L-homoserine

Modifications
Strain Maximum production lysAEc thrBEc metAEc ldhAEc adhEEc pflBEc ptsGEc galPEc ppcEc iclREc arcAEc aspAEc glkEc asdEc glfZm metLEc rhtAEc galREc eamAEc thrAEc gltBEc addEc amnEc ADO1Sc aspCEc thrCEc gltAEc pykAEc pykFEc tdcCEc
E. coli HM3 (pBRmetL) 1,400 mg/L
E. coli HM4 (pBRmetL) 6,780 mg/L
E. coli HM4 (pBRmetL–pNrhtA) 33,420 mg/L
E. coli LJL12 35,800 mg/L
E. coli HM5 (pBRmetL–pNrhtA) 39,540 mg/L
E. coli W-H18/pM2/pR1 110,800 mg/L
E. coli HS27 119,960 mg/L

Substrate yield in Flask for L-homoserine

Modifications
Strain Maximum production lysAEc thrBEc metAEc ldhAEc adhEEc pflBEc metLEc rhtAEc ptsGEc galPEc ppcEc iclREc arcAEc aspAEc glkEc asdEc glfZm atpFEc atpHEc thrCEc gltAEc pykAEc pykFEc thrAEc
E. coli W-H7 0.00331 g/g of sustrate
E. coli W-H7/pM1/pR1 0.05144 g/g of sustrate
E. coli W-9/pM1/pR1 0.21158 g/g of sustrate
E. coli W-H17/pM1/pR1 0.23142 g/g of sustrate
E. coli W-10/pM1/pR1 0.24464 g/g of sustrate
E. coli HM4 (pBRmetL–pNrhtA) 0.26 g/g of sustrate
E. coli LJL12 0.35 g/g of sustrate
E. coli W-H17/pM2/pR1 0.39011 g/g of sustrate
E. coli W-H17/pM2/pR2 0.39011 g/g of sustrate
E. coli W-H18/pM2/pR1 0.44962 g/g of sustrate
E. coli W-H19/pM2/pR1 0.45623 g/g of sustrate
E. coli W-H20/pM2/pR1 0.46284 g/g of sustrate

Substrate yield in Fed-Batch for L-homoserine

Modifications
Strain Maximum production lysAEc thrBEc metAEc ldhAEc adhEEc pflBEc ptsGEc galPEc ppcEc iclREc arcAEc aspAEc glkEc asdEc glfZm metLEc rhtAEc galREc eamAEc thrAEc gltBEc addEc amnEc ADO1Sc aspCEc thrCEc
E. coli HM4 (pBRmetL) 0.13 g/g of sustrate
E. coli HM4 (pBRmetL–pNrhtA) 0.24 g/g of sustrate
E. coli HS27 0.41 g/g of sustrate
E. coli W-H18/pM2/pR1 0.63475 g/g of sustrate

Volumetric productivity in Flask for L-homoserine

Modifications
Strain Maximum production lysAEc thrBEc metAEc ldhAEc adhEEc pflBEc ptsGEc galPEc ppcEc iclREc arcAEc aspAEc glkEc asdEc glfZm metLEc rhtAEc atpFEc atpHEc
E. coli W-H19/pM2/pR1 590 mg/L/h
E. coli W-H20/pM2/pR1 630 mg/L/h
E. coli W-H18/pM2/pR1 730 mg/L/h

Volumetric productivity in Fed-Batch for L-homoserine

Modifications
Strain Maximum production lysAEc thrBEc metAEc ldhAEc adhEEc pflBEc ptsGEc galPEc ppcEc iclREc arcAEc aspAEc glkEc asdEc glfZm metLEc rhtAEc galREc eamAEc thrAEc gltBEc addEc amnEc ADO1Sc aspCEc thrCEc gltAEc pykAEc pykFEc
E. coli LJL12 820 mg/L/h
E. coli HS27 1,310 mg/L/h
E. coli W-H18/pM2/pR1 1,820 mg/L/h