Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for L-methionine

Modifications
Strain Maximum production metJEc metAEc yjeHEc metIEc lysAEc
E. coli W3110 0 mg/L
E. coli W3110 ΔmetJ/pTrcA* 202.64 mg/L
E. coli W3110 ΔmetJ (pTrcA*H) 413.16 mg/L
E. coli W3110 ΔmetJΔmetI (pTrcA*H) 593.3 mg/L
E. coli W3110 ΔmetJΔmetIΔlysA/pTrcA*H 4,080 mg/L

Titer in Fed-Batch for L-methionine

Modifications
Strain Maximum production metJEc metIEc lysAEc metAEc yjeHEc thrBEc
E. coli W3110 ΔmetJΔmetIΔlysAΔthrB/pTrcA*H 4,090 mg/L
E. coli W3110 ΔmetJΔmetIΔlysA/pTrcA*H 9,750 mg/L

Substrate yield in Batch for L-methionine

Modifications
Strain Maximum production metJEc metIEc metAEc yjeHEc lysAEc thrBEc
E. coli W3110 ΔmetJΔmetIΔthrB/pTrcA*H 0.02 g/g of sustrate
E. coli W3110 ΔmetJΔmetI (pTrcA*H) 0.03 g/g of sustrate
E. coli W3110 ΔmetJΔmetIΔlysA/pTrcA*H 0.19 g/g of sustrate
E. coli W3110 ΔmetJΔmetIΔlysAΔthrB/pTrcA*H 0.2 g/g of sustrate

Substrate yield in Fed-Batch for L-methionine

Modifications
Strain Maximum production metJEc metIEc lysAEc metAEc yjeHEc
E. coli W3110 ΔmetJΔmetIΔlysA/pTrcA*H 0.14 g/g of sustrate

Volumetric productivity in Fed-Batch for L-methionine

Modifications
Strain Maximum production metJEc metIEc lysAEc metAEc yjeHEc
E. coli W3110 ΔmetJΔmetIΔlysA/pTrcA*H 200 mg/L/h