Chen, Minliang; Han, Chao; Zhou, Peng; Shi, Run; Xing, Zhiwei; Chen, Qianqian; Xie, Gou-an; Xie, Rufei; Tan, Wei & Liang, Hengyu. Rational metabolic engineering of Escherichia coli for the industrial-scale production of l-phenylalanine. Bioresource Technology. 2025, 426, 132325.
Strains
- Escherichia coli W3110MT
- Escherichia coli PHE01
- Escherichia coli PHE07
- Escherichia coli PHE08
- Escherichia coli PHE09
- Escherichia coli PHE10
- Escherichia coli PHE11
- Escherichia coli PHE12
- Escherichia coli PHE13
- Escherichia coli PHE14
- Escherichia coli PHE15
- Escherichia coli PHE16
- Escherichia coli PHE17
Plasmids
Metabolite production
-
L-phenylalanine
-
Titer
- 77.15 g/L (Escherichia coli PHE08 in Fed-Batch)
- 80.84 g/L (Escherichia coli PHE09 in Fed-Batch)
- 103.15 g/L (Escherichia coli PHE17 in Fed-Batch)
- 105.36 g/L (Escherichia coli PHE14 in Fed-Batch)
- 101.58 g/L (Escherichia coli PHE13 in Fed-Batch)
- 92.21 g/L (Escherichia coli PHE12 in Fed-Batch)
- 94.72 g/L (Escherichia coli PHE11 in Fed-Batch)
- 88.26 g/L (Escherichia coli PHE10 in Fed-Batch)
- 74.01 g/L (Escherichia coli PHE07 in Fed-Batch) Substrate yield
- 0.208 g/g of sustrate (Escherichia coli PHE08 in Fed-Batch)
- 0.206 g/g of sustrate (Escherichia coli PHE09 in Fed-Batch)
- 0.229 g/g of sustrate (Escherichia coli PHE17 in Fed-Batch)
- 0.229 g/g of sustrate (Escherichia coli PHE14 in Fed-Batch)
- 0.229 g/g of sustrate (Escherichia coli PHE13 in Fed-Batch)
- 0.227 g/g of sustrate (Escherichia coli PHE12 in Fed-Batch)
- 0.222 g/g of sustrate (Escherichia coli PHE11 in Fed-Batch)
- 0.207 g/g of sustrate (Escherichia coli PHE10 in Fed-Batch)
- 0.207 g/g of sustrate (Escherichia coli PHE07 in Fed-Batch)