Zhang, Xiaoling; Li, Yanan; Wang, Kang; Yin, Jilong; Du, Yuxuan; Yang, Zhen; Pan, Xuewei; You, Jiajia & Rao, Zhiming. Construction of antibiotic-free riboflavin producer in Escherichia coli by metabolic engineering strategies with a plasmid stabilization system. Synthetic and Systems Biotechnology. 2025, 10(2), 346-355.
Strains
- Escherichia coli JM109
- Escherichia coli MG1655
- Escherichia coli EF-1
- Escherichia coli EF-2-1
- Escherichia coli EF-2-2
- Escherichia coli EF-2
- Escherichia coli EF-3
- Escherichia coli EF-4-1
- Escherichia coli EF-4-2
- Escherichia coli EF-4
- Escherichia coli EF-5-1
- Escherichia coli EF-5
- Escherichia coli EF-6
- Escherichia coli EF-7
- Escherichia coli EF-7EP
- Escherichia coli EF-8
- Escherichia coli EF-9
- Escherichia coli EF-10
- Escherichia coli EF-11
- Escherichia coli EF-12
- Escherichia coli EF-13
- Escherichia coli EF-14
- Escherichia coli EF-15
- Escherichia coli EF-16
- Escherichia coli EF-17
- Escherichia coli EF-18
- Escherichia coli YONT
- Escherichia coli YONT/pasyonT
- Escherichia coli YONTPI
- Escherichia coli WTPI
Plasmids
Metabolite production
-
riboflavin
-
Titer
- 38.8 mg/L (Escherichia coli EF-1 in Flask)
- 309.9 mg/L (Escherichia coli EF-2 in Flask)
- 480.0 mg/L (Escherichia coli EF-3 in Flask)
- 660.0 mg/L (Escherichia coli EF-4 in Flask)
- 762.5 mg/L (Escherichia coli EF-5 in Flask)
- 964.1 mg/L (Escherichia coli EF-6 in Flask)
- 1093.4 mg/L (Escherichia coli EF-7 in Flask)
- 643.8 mg/L (Escherichia coli EF-10 in Flask)
- 1280.8 mg/L (Escherichia coli EF-15 in Flask)
- 1378.2 mg/L (Escherichia coli EF-16 in Flask)
- 142.5 mg/L (Escherichia coli EF-17 in Flask)
- 1287.0 mg/L (Escherichia coli EF-18 in Flask)
- 1970.7 mg/L (Escherichia coli EF-18 in Flask)
- 2205.5 mg/L (Escherichia coli EF-16 in Flask)
- 11.6 g/L (Escherichia coli EF-16 in Fed-Batch)
- 11.5 g/L (Escherichia coli EF-18 in Fed-Batch) Substrate yield
- 110.2 mg/g of sustrate (Escherichia coli EF-16 in Flask)
- 80.3 mg/g of sustrate (Escherichia coli EF-16 in Fed-Batch)
- 90.4 mg/g of sustrate (Escherichia coli EF-18 in Fed-Batch)