Huang, Wen-Zhang; Xu, Jian-Zhong & Zhang, Wei-Guo. Enhancing nicotinamide mononucleotide production from glucose in Escherichia coli by genetic engineering. Systems Microbiology and Biomanufacturing. 2024, 4(1), 138-149.
Strains
- Escherichia coli BL21(DE3)
- Escherichia coli ZY01
- Escherichia coli ZY02
- Escherichia coli ZY03
- Escherichia coli ZY04
- Escherichia coli ZY05
- Escherichia coli ZY06
- Escherichia coli ZY07
- Escherichia coli ZY08
- Escherichia coli ZY09
- Escherichia coli ZY10
- Escherichia coli ZY11
- Escherichia coli ZY12
- Escherichia coli ZY13
- Escherichia coli ZY14
- Escherichia coli ZY15
- Escherichia coli ZY16
- Escherichia coli ZY17
Plasmids
Metabolite production
-
β-nicotinamide D-ribonucleotide
-
Titer
- 1.61 g/L (Escherichia coli ZY17 in Flask)
- 13.3 g/L (Escherichia coli ZY17 in Fed-Batch)
- 26.2 mg/L (Escherichia coli ZY01 in Flask)
- 43.6 mg/L (Escherichia coli ZY02 in Flask)
- 82.3 mg/L (Escherichia coli ZY03 in Flask)
- 137.1 mg/L (Escherichia coli ZY04 in Flask)
- 208.6 mg/L (Escherichia coli ZY08 in Flask)
- 268.2 mg/L (Escherichia coli ZY10 in Flask)
- 451.2 mg/L (Escherichia coli ZY12 in Flask)
- 842.6 mg/L (Escherichia coli ZY16 in Flask) Volumetric productivity
- 1.11 g/L/h (Escherichia coli ZY17 in Fed-Batch)